© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

In 1887 Helmholtz discussed the foundations of measurement in science as a last contribution to his philosophy of knowledge. This essay borrowed from earlier debates on the foundations of mathematics, on the possibility of quantitative psychology, and on the meaning of temperature measurement. Late nineteenth-century scrutinisers of the foundations of mathematics made little of Helmholtz’s essay. Yet it inspired two mathematicians with an eye on physics, and a few philosopher-physicists. The aim of the present paper is to situate Helmholtz’s contribution (...) in this complex array of nineteenth-century philosophies of number, quantity, and measurement.Author Keywords: Helmholtz; Measurement; Arithmetic; P. Du Bois-Reymond; H. and R. Grassmann; J. von Kries. (shrink)

Local sentences were introduced by Ressayre in [6] who proved certain remarkable stretching theorems establishing the equivalence between the existence of finite models for these sentences and the existence of some infinite well ordered models. Two of these stretching theorems were only proved under certain large cardinal axioms but the question of their exact strength was left open in [4]. Here we solve this problem, using a combinatorial result of J. H. Schmerl [7]. In fact, we show that the stretching (...) principles are equivalent to the existence of n -Mahlo cardinals for appropriate integers n. This is done by proving first that for every integer n, there is a local sentence φn having well ordered models of order type τ, for every infinite ordinal τ > ω which is not an n -Mahlo cardinal. (shrink)

La Semaine d'épigraphie créto-mycénienne a été organisée par l'École française d'Athènes du 24 au 28 mars 1998, dans le but de réunir, pour quelques séances de travail, des savants reconnus et de jeunes doctorants spécialisés dans l'étude des écritures linéaires A et B. Chacun des participants a présenté un état de ses recherches personnelles : M.-L. Bech Nosch, L'administration des textes en Crète centrale, hors des séries Lc/Le/Ln ; Chr. Boulotis, Les nouveaux documents en linéaire A d'Akrotiri (Théra) : remarques (...) préliminaires ; P. Carlier, wa-na-ka derechef. Nouvelles réflexions sur les royautés mycéniennes; P. Darcque, Archives réelles, archives virtuelles en linéaire B; H. Landenius Enegren, Some Problems of the Prosopography of Knossos; J. T. Killen, The Pylos Ta Tablets Revisited ; S. Lupack, The Role of the Religious Sector in Mycenaean Economics; J.-P. Olivier, Le syllabaire chyproclassique : un inventaire; M. Perna, Gli ideogrammi dei vasi in lineare A ; Fr. Rougemont, Quelques problèmes liés à l'étude des «collecteurs» dans les tablettes en linéaire B; M.-St. Speciale, Gli antroponimi in lineare B di Cnosso e la Creta del TM II-III; M. Tsipopoulou, The Hieroglyphic Archive at Petras, Siteia ; C. Varias Garcia, Antroponimia micénica en las tablillas de h sene B de Cnoso y en Micenas. (shrink)

Plagiarism detection is the process of finding similarities on electronic based documents. Recently, this process is highly required because of the large number of available documents on the internet and the ability to copy and paste the text of relevant documents with simply Control+C and Control+V commands. The proposed solution is to investigate and develop an easy, fast, and multi-language support plagiarism detector with the easy of one click to detect the document plagiarism. This process will be done with the (...) support of intelligent system that can learn, change and adapt to the input document and make a cross-fast search for the content on the local repository and the online repository and link the content of the file with the matching content everywhere found. Furthermore, the supported document type that we will use is word, text and in some cases, the pdf files –where is the text can be extracting from them- and this made possible by using the DLL file from Word application that Microsoft provided on OS. The using of DLL will let us to not constrain on how to get the text from files; and will help us to apply the file on our Delphi project and walk throw our methodology and read the file word by word to grantee the best working scenarios for the calculation. In the result, this process will help in the uprising the documents quality and enhance the writer experience related to his work and will save the copyrights for the official writer of the documents by providing a new alternative tool for plagiarism detection problem for easy and fast use to the concerned Institutions for free. (shrink)

In spite of the seeming heterogeneity of topics in its title - Revolutions, Systems, and Theories - this volume purports to be something more than a random collection of Essays in Political Philosophy. The Colloquium of the Philosophy Department of the University of Western Ontario (29-31 Octo­ ber, 1971) at which initial versions of the first eight papers were delivered was entitled 'Political Theory'; and while the organizers anticipated and indeed welcomed topicality in the issues accorded priority arid in the (...) empirical evidence invoked, they were also hoping for a reasonably comprehensive explorat ion of some of the central issues of political philosophy. For this reason it was quickly decided that in such a field a philosophical focus on clarification of ordering concepts required the suppIement - and test - of researches into more particular subject maUers by social scientists. Thus, to speak in general terms (where the specializatlons and their taxonomies multi­ ply fissiparously!), contributors include political scientists, economists and sociologists (Barnard, Baston, Tullock, Rapoport) as well as philosophers (Scriven, Morgenbesser, Braybrooke, TayIor), and juxtaposed as proponents and commentators ·to generate exchanges across disciplinary frontiers. While the five additional invited papers are alI by professional philosophers, they extend the original Colloquium either by continuing controversy on its funda­ mental issues (e. g., Rubinoff, Nielsen, Roy) or by their continued explorations in what are acknowledged to be boundary areas (e. g., Schick, Wartofsky). The greatest topical emphasis is that on revolution. (shrink)

The degree of justification for a judgment of artistic value is normally directly proportional to the size of the comparison class that is brought to bear in making that judgment. If that comparison class is very small or nonexistent, justified judgments are unlikely or impossible. So which artworks, if any, are comparable? The claim that evaluative comparisons can be made among artworks within a fine-grained category—abstract expressionist paintings, for example—is relatively uncontroversial. But is there any way that we can compare (...) artworks that have only a very coarse-grained category in common (such as two works of visual art), or that are in completely different coarse-grained categories (such as a symphony and a sculpture)? I argue that both very similar and very different artworks can be compared evaluatively. Comparisons within fine-grained categories are common, and reflection on critical practices shows us that they depend crucially on qualitative assessments of artistically valuable properties. Once qualitative assessment is recognized as underwriting artistic criticism, it follows that even rough-grained categorization provides no essential barrier to comparison, securing the possibility of well-justified evaluations of disparate artworks. (shrink)

Die griechische Weltauffassung unterscheidet sich van der modernen durch den Gedanken der Begrenztheit des Weltalls, das sich dem spekulativen Blick seinem Wesen nach erschliesst. Die inPlaton's Timaios gipfelnde Kosmologie bestimmt das Weltall nach den Wesensgesichtspunkten der Endlichkeit, der Einzigkeit, der Lebendigkeit und der Vollkommenheit.Platon's Holismus bezieht die leblose und die lebende Natur unter die Idee des Lebens des Kosmos, dessen „Teile” die in der Erfahrung gegebenen Lebenserscheinungen sind. Sein von innen her und intuitiv aufgebautes Weltbild, das die Erscheinungen von oben (...) herab hierarchisch ordnet, tritt dem AtomismusDemokrits gegenüber, der in umgekehrtem Verfahren die höheren Strukturen auf den einen Baustoff aller Dinge reduziert. Der Gegensatz zum Holismus offenbart sich in allen Bestimmungen: fürDemokrit sind der Kosmoi unbegrenzt viele, es gibt nur Ansammlungen von Atomen, es fehlen Einzigkeit und Vollkommenheit, sowie ein Begriff des Lebens als des zentralen Geschehens.Die neuzeitliche Forschung verzichtet auf die spekulativen Bestimmungen des Ganzen, aber der bei den Griechen dogmatische Gegensatz holistischer und atomistischer Betrachtungsweise lebt fort als Gegensatz geistiger Einstellung. Der neuzeitliche Holismus ist ein empirischer, beschränkter, aber bei ihm liegt dieselbe Intuition des sich organisch gestaltenden Gesamtlebens zu Grunde wei beiPlaton. Nur wäre es, unrichtig, diesen Holismus als synthetisch zu bezeichnen. Synthetisches Denken erhebt sich immer auf analytischem Boden. Jede Synthese hat eine offene Grenze. Die Art aber, wie der Holismus die vereinzelten Lebenserscheinungen auf umfassendere Ganzheiten bezieht, ist eine intuitive. Das Band der Erscheinungen wird nicht durch äusseres Beziehen gestiftet, sondern geschaut nach Analogie einer inneren Erfahrung.Im Gegensatz zum Atomismus, der als real nur die Atome und deren Verhältnisse gelten lässt, erkennt der Holismus stufenartig aufgebaute Einheitsarten an, in denen die höheren die niedrigeren beherrschen, ohne sie zu Elementen herabzudrücken. Die Metaphysik, auf der Suche nach dem Zusammenhang zwischen dem Menschenleben und der Natur ist an der empirischen Aufweisung das Einzelne übersteigender Lebensverbände wie sie der Holismus zu Tage fordert aufs Höchste interessiert.The conception of the world with Greek thinkers generally differs from contemporary thought in the idea of the limitation of the world whose essence manifests itself to speculative thinking. The cosmology which culminates inPlato's Timaios attributes to the whole of being the properties of finiteness, uniqueness, life and perfection.Plato's holism subsumes inanimate and living nature under the idea of cosmic life, the “parts” of which are constituted by life-phenomena given in experience. His world-conception, constructed from within and intuitively, which ranges phenomena in descending order, is opposed to the atomism ofDemocritos which reduces the higher structures to the one equal material of all things. This opposition manifests itself in all essential points: toDemocritos there are worlds in infinite number, only accumulations of atoms are real, uniqueness and perfection are lacking as well as the idea of Life as a central reality.Modern research foregoes the attempt to determine the whole speculatively, but holistic and atomistic ways of thinking, after having been dogmatically applied by the Greeks, continue to exist as opposed types of mental attitude. Contemporary holism may be empirical and limited in application, but it is directed by the same intuition of life articulating itself organically as wasPlato's. It would be incorrect, however, to characterize holism as synthetical, since all synthetics is based upon analysis. The bounds of synthesis are never fixed ones, nor does it ever determine essence. Holism's way of subsuming single life-phenomena under more comprehensive wholes is an intuitional one, the connections which it creates between phenomena are not external ones, but apprehended intuitively in analogy to inner experience.—In distinction to atomism, which only admits as real atoms and their mutual relations, holism poses groups of unities, classified in grades, the higher of which dominate the lower, without debasing them to elements. As metaphysics is concerned to discover a connection between Nature and human life, it must be highly interested in the empirical demonstration, such as holism offers, of connections of life, surpassing individual being. (shrink)

The long-term persistence of neurotic symptoms, such as anxiety, poses difficult problems for any psychological theory. An attempt is made to revive the Watson-Mowrer conditioning theory and to avoid the many criticisms directed against it in the past. It is suggested that recent research has produced changes in learning theory that can be used to render this possible. In the first place, the doctrine of equipotentiality has been shown to be wrong, and some such concept as Seligman's “preparedness” is required, (...) that is the notion that certain CS are biologically prepared to be more readily connected with anxiety responses than others. In the second place, the law of extinction has to be amended, and the law of incubation or enhancement added, according to which the exposure of the CS-only may, under certain specified conditions, have the effect of increasing the strength of the CR, rather than reducing it. The major conditions favouring incubation are Pavlovian B conditioning, that is a type of conditioning in which the CR is a drive; a strong UCS, and short exposure of the CS-only. (shrink)

Originally published: London: Allen & Unwin, 1936.

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